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I1882
Sigma
Insulin from bovine pancreas
lyophilized powder, ≥25 USP units/mg, γ-irradiated, cell culture tested
| CAS Number: | 11070-73-8 |
| Linear Formula: | C254H377N65O75S6 |
| Molecular Weight: | 5733.49 |
| EC Number: | 234-291-2 |
| MDL number: | MFCD00131380 |
Description
| Frequently Asked Questions | Live Chat and Frequently Asked Questions are available for this Product. |
| Biochem/physiol Actions | Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. |
| Reconstitution | To prepare 10 mg/ml stock solution, add 10 ml of acidified H2O (pH ≤2) - prepared by addition of glacial acetic acid (approx. 0.1 ml). |
| Physical form | powder-0 °C; solution stable 2-8 °C, 1 year |
Properties
| sterility | γ-irradiated |
| form | lyophilized powder |
| potency | 0.001-20 μg/mL |
| suitability | cell culture tested |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
Related Products
References
| reference | Smith, L.F., Species variation in the amino acid sequence of insulin. Am. J. Med. 40, 662-666, (1966) |
| Kono, T., Insulin-sensitive glucose transport. Vitam. Horm. 7, 103-154, (1988) | |
| Merck | Merck 13,5003 |
